Solubilization of poorly water-soluble drugs has been a very important issue in screening
studies of new chemical entities as well as formulation research. Various techniques are …

This review explores sustainable strategies for enhancing the solubility of poorly water-
soluble pharmaceutical active ingredients (PAIs), focusing on hydrotropy and co-solvency …

ABSTRACT A new, simple, safe, accurate and reproducible titrimetric method was
developed for the quantitative estimation of frusemide in the bulk drug sample and tablets by …

A novel, simple, safe, sensitive, and economical method of spectrophotometric estimation in
UV region has been developed using 5M urea solution as hydrotropic solubilizing agent for …

Anovel, safe and sensitive method of spectrophotometric estimation in the ultraviolet region
has been developed using1M lignocaine hydrochloride (an economic drug) as a hydrotropic …

The present investigation illustrates the application of mixed hydrotropy. The enhancement
in the solubility of ketoprofen in a mixed hydrotropoic solution containing 30% urea and 30 …

Solubilisation of poorly soluble drugs is encountered as a challenge in screening studies of
new chemical entities as well as its formulation development is obstacle. A number of …

The dominance of searching for water‐soluble drugs in drug discovery has radically
amplified the obstacles. Although poorly soluble drugs signify a class of active …

An acceptable, safe, and green technique for solubilization of poorly soluble drugs is the
major important initial step for their handling through analytical work. Various procedures …

In the present investigation, hydrotropic solubilization technique has been employed to
solubilize the slightly water soluble topical antifungal drug, benzoic acid (by 1.0 M calcium …