Coupling of mechanical deformation and electromagnetic fields in biological cells
The cell, as the most fundamental unit of life, is a microcosm of biology in which the
confluence of nearly all aspects of classical physics (mechanics, statistical physics …
confluence of nearly all aspects of classical physics (mechanics, statistical physics …
Integrating the active process of hair cells with cochlear function
AJ Hudspeth - Nature Reviews Neuroscience, 2014 - nature.com
Uniquely among human senses, hearing is not simply a passive response to stimulation.
Our auditory system is instead enhanced by an active process in cochlear hair cells that …
Our auditory system is instead enhanced by an active process in cochlear hair cells that …
The physiology of mechanoelectrical transduction channels in hearing
R Fettiplace, KX Kim - Physiological reviews, 2014 - journals.physiology.org
Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
[HTML][HTML] Making an effort to listen: mechanical amplification in the ear
AJ Hudspeth - Neuron, 2008 - cell.com
The inner ear's performance is greatly enhanced by an active process defined by four
features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous …
features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous …
The remarkable cochlear amplifier
This composite article is intended to give the experts in the field of cochlear mechanics an
opportunity to voice their personal opinion on the one mechanism they believe dominates …
opportunity to voice their personal opinion on the one mechanism they believe dominates …
The physics of hearing: fluid mechanics and the active process of the inner ear
T Reichenbach, AJ Hudspeth - Reports on Progress in Physics, 2014 - iopscience.iop.org
Most sounds of interest consist of complex, time-dependent admixtures of tones of diverse
frequencies and variable amplitudes. To detect and process these signals, the ear employs …
frequencies and variable amplitudes. To detect and process these signals, the ear employs …
[HTML][HTML] Drosophila auditory organ genes and genetic hearing defects
The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate
hair cells, and both are specified by atonal family genes. Using a whole-organ knockout …
hair cells, and both are specified by atonal family genes. Using a whole-organ knockout …
Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
Mutations in myosin-VIIa (MYO7A) cause Usher syndrome type 1, characterized by
combined deafness and blindness. MYO7A is proposed to function as a motor that tensions …
combined deafness and blindness. MYO7A is proposed to function as a motor that tensions …
A bundle of mechanisms: inner-ear hair-cell mechanotransduction
In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates
mechanically-gated channels (MGCs). Hair bundles monitor orientation of the head, its …
mechanically-gated channels (MGCs). Hair bundles monitor orientation of the head, its …
Quantifying entropy production in active fluctuations of the hair-cell bundle from time irreversibility and uncertainty relations
We introduce lower bounds for the rate of entropy production of an active stochastic process
by quantifying the irreversibility of stochastic traces obtained from mesoscopic degrees of …
by quantifying the irreversibility of stochastic traces obtained from mesoscopic degrees of …