Investigations on binding strength differences of non-covalent protein complex components
were performed by mass spectrometry. T4 fibritin foldon (T4Ff) is a well-studied miniprotein …

With Intact Transition Epitope Map**-Thermodynamic Weak-force Order (ITEM-TWO)
analysis in combination with molecular modeling, the phosphorylation-dependent molecular …

Antibody-based point-of-care diagnostics have become indispensable for modern medicine.
In-depth analysis of antibody recognition mechanisms is the key to tailoring the accuracy …

Precision medicine requests accurate serological inspections to precisely stratify patients for
targeted treatment. Intact transition epitope map** analysis proved surrogate …

Background Bioanalytical methods that enable rapid and high-detail characterization of
binding specificities and strengths of protein complexes with low sample consumption are …

Intact Transition Epitope Map**—One-step Non-covalent force Exploitation (ITEM-ONE)
analysis reveals an assembled epitope on the surface of Pertuzumab, which is recognized …

We investigated the influence of a solvent's composition on the stability of desorbed and
multiply charged RNAse S ions by analyzing the non-covalent complex's gas-phase …

We have performed CID experiments on a triple quadrupole instrument, lowering the
collision gas pressure by 50 times compared to its conventional value. The results show that …

Pepsin, because of its optimal activity at low acidic pH, has gained importance in mass
spectrometric proteome research as a readily available and easy-to-handle protease …

Accurate formation of antibody‐antigen complexes has been relied on in both, multitudes of
scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically …