Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy.
Understanding how selective pressure from chemotherapy directs the evolution of urothelial …

Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Malignant gliomas are lethal cancers that display striking cellular heterogeneity. A highly
tumorigenic glioma tumor subpopulation, termed cancer stem cells or tumor-initiating cells …

Pancreatic ductal adenocarcinoma (PDAC) still ranking 4th in the order of fatal tumor
diseases is characterized by a profound tumor stroma with high numbers of tumor …

L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described
with important functions in the development of the nervous system. Subsequent work …

Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic
advances in other solid cancers, the treatment of these malignant gliomas remains …

The L1 cell adhesion molecule (L1CAM) plays a major role in the development of the
nervous system and in the malignancy of human tumors. In terms of biological function …

Type 2 diabetes mellitus (T2DM) is associated with hyperglycemia and a risk to develop
pancreatic ductal adenocarcinoma (PDAC), one of the most fatal malignancies. Cancer stem …