Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine,
sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect …

Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in
humans, with the poor metabolizer trait being inherited in an autosomal recessive fashion …

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic
advance in psychopharmacology. As a result, the discovery of these agents marks a …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

ABSTRACT A genetic polymorphism in the metabolism of the anticonvulsant drug (S)-
mephenytoin has been well documented in humans. There are marked interracial …

The human CYP2Cs are an important subfamily of P450 enzymes that metabolize
approximately 20% of clinically used drugs. There are four members of the subfamily …

The application of pharmacogenetics holds great promise for individualized therapy.
However, it has little clinical reality at present, despite many claims. The main problem is that …