The Golgi apparatus is known to underpin many important cellular homeostatic functions,
including trafficking, sorting and modifications of proteins or lipids. These functions are …

More than a decade ago, the term “next-generation” sequencing was coined to describe
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlap** clinically with type I IFN-mediated disease due to gain-of-function in STING, a …

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha …

Mendelian autoinflammatory diseases characterized by constitutive activation of the type I
interferon pathway, the so-called type I interferonopathies, constitute a rapidly expanding …

Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are
recognized to cause chronic granulomatous disease (CGD), a severe primary …

Protein coats are supramolecular complexes that assemble on the cytosolic face of
membranes to promote cargo sorting and transport carrier formation in the endomembrane …

Background & Aims RNA editing introduces nucleotide changes in RNA sequences. Recent
studies have reported that aberrant adenosine-to-inosine RNA editing is implicated in …

Abstract Purpose of Review Type I interferons (IFNαβ) induce the expression of hundreds of
genes; thus, it is unsurprising that the initiation, transmission, and resolution of the IFNαβ …

Background Copa syndrome is a rare autosomal dominant disorder with abnormal
intracellular vesicle trafficking. The objective of this work is to expand the knowledge about …