Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

L Renia, YS Goh, A Rouers, N Le Bert, WN Chia… - Nature …, 2022 - nature.com
Understanding the impact of age on vaccinations is essential for the design and delivery of
vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of …

Immunological Studies to Understand Hybrid/Recombinant Variants of SARS-CoV-2

VP Chavda, T Mishra, S Vuppu - Vaccines, 2022 - mdpi.com
The zoonotic SARS-CoV-2 virus was present before the onset of the pandemic. It undergoes
evolution, adaptation, and selection to develop variants that gain high transmission rates …

Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection

MZ Tay, A Rouers, SW Fong, YS Goh… - EMBO molecular …, 2022 - embopress.org
Abstract The SARS‐CoV‐2 Delta (B. 1.617. 2) variant is capable of infecting vaccinated
persons. An open question remains as to whether deficiencies in specific vaccine‐elicited …

Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals

YS Goh, A Rouers, SW Fong, NZ Zhuo, PX Hor… - Frontiers in …, 2022 - frontiersin.org
The emergence of new SARS-CoV-2 variants, such as the more transmissible Delta and
Omicron variants, has raised concerns on efficacy of the COVID-19 vaccines. Here, we …

Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy

Q Chen, A Chia, SK Hang, A Lim, WK Koh… - Cellular & molecular …, 2023 - nature.com
Solid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are
susceptible to develo** severe COVID-19. Here, we analyze the Spike-specific T-cell …

Prolonged inflammation in patients hospitalized for coronavirus disease 2019 (COVID‐19) resolves 2 years after infection

SW Fong, YS Goh, A Torres‐Ruesta… - Journal of Medical …, 2023 - Wiley Online Library
Long‐term complications from coronavirus disease 2019 (COVID‐19) are concerning, as
survivors can develop subclinical multiorgan dysfunction. It is unknown if such complications …

Heterologous booster vaccination with CoronaVac following prime vaccination with mRNA vaccine

YS Goh, SW Fong, A Rouers, ZW Chang… - Clinical & …, 2022 - Wiley Online Library
Objective Despite the high vaccine efficacy of mRNA COVID‐19 vaccines, there are
individuals who developed excessive reactogenic and/or allergic responses after the first …

Variant-Specific IgA Protects Against Omicron Infection

YS Goh, SW Fong, PX Hor, CY Loh… - The Journal of …, 2024 - academic.oup.com
Background The emergence of rapidly evolving severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has …

Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta …

YS Goh, SW Fong, MZ Tay, A Rouers, ZW Chang… - Scientific Reports, 2023 - nature.com
Identification of the risk factors and the high-risk groups which are most vulnerable is critical
in COVID-19 disease management at a population level. Evaluating the efficacy of …

First SARS-CoV-2 Omicron infection as an effective immune booster among mRNA vaccinated individuals: final results from the first phase of the PRIBIVAC …

XY Poh, IR Lee, CW Tan, JM Chavatte, SW Fong… - …, 2024 - thelancet.com
Summary Background Understanding how SARS-CoV-2 breakthrough infections impacts
the breadth of immune responses against existing and pre-emergent SARS-CoV-2 strains is …