Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …

The brain is unique and the most complex organ of the body, containing neurons and
several types of glial cells of different origins and properties that protect and ensure normal …

Epilepsy can be both a primary pathology and a secondary effect of many neurological
conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in …

Background Glioblastoma (GBM), a prevalent malignant neoplasm within the neuro-
oncological domain, has been a subject of considerable scrutiny. Macrophages, serving as …

Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …

Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …

Glioblastoma (GBM) is the most common malignant brain tumor in adults, and
immunotherapies and genetic therapies for GBM have evolved dramatically over the past …

Brain tumors and brain metastases induce changes in brain tissue remodeling that lead to
immunosuppression and trigger an inflammatory response within the tumor …

Oncostatin M (OSM) is a pleiotropic cytokine involved in a variety of inflammatory responses
such as wound healing, liver regeneration, and bone remodeling. As a member of the …

Different functional states determine glioblastoma (GBM) heterogeneity. Brain cancer cells
coexist with the glial cells in a functional syncytium based on a continuous metabolic …