Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

J Li, K Pu - Chemical Society Reviews, 2019 - pubs.rsc.org
Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical
agents to control the light pathways in cells, tissues and living organisms for specific …

Polymer–drug conjugate therapeutics: advances, insights and prospects

I Ekladious, YL Colson, MW Grinstaff - Nature reviews Drug discovery, 2019 - nature.com
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Photosensitizers with aggregation‐induced emission: Materials and biomedical applications

F Hu, S Xu, B Liu - Advanced materials, 2018 - Wiley Online Library
Photodynamic therapy is arising as a noninvasive treatment modality for cancer and other
diseases. One of the key factors to determine the therapeutic function is the efficiency of …

Nanotechnology for multimodal synergistic cancer therapy

W Fan, B Yung, P Huang, X Chen - Chemical reviews, 2017 - ACS Publications
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …

Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs

J Chen, Z Zhang, J Ma, A Nezamzadeh-Ejhieh… - Dalton …, 2023 - pubs.rsc.org
Cancer has become the second leading reason for death in the world. Still, cancer therapy
development is exceptionally challenging because the tumor microenvironment is very …

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

W Zhang, X Hu, Q Shen, D **ng - Nature communications, 2019 - nature.com
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with
normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …

Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke

Y Li, J Liao, L **ong, Z **ao, F Ye, Y Wang… - Journal of Controlled …, 2024 - Elsevier
Ischemia-reperfusion injury is caused by excessive production of reactive oxygen species
(ROS) and inflammation accompanied by ischemic injury symptoms and blood–brain barrier …

ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury

H Yu, F **, D Liu, G Shu, X Wang, J Qi, M Sun… - …, 2020 - pmc.ncbi.nlm.nih.gov
Acute kidney injury (AKI) caused by sepsis is a serious disease which mitochondrial
oxidative stress and inflammatory play a key role in its pathophysiology. Ceria nanoparticles …

Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria

AT Dharmaraja - Journal of medicinal chemistry, 2017 - ACS Publications
Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …