Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease
The blood–brain barrier (BBB) tightly controls the molecular exchange between the brain
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …
Connecting metabolism and gonadal function: novel central neuropeptide pathways involved in the metabolic control of puberty and fertility
Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …
that can be adjusted to body metabolic status. Reproductive maturation and function can be …
The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus
K Chachlaki, J Garthwaite, V Prevot - Nature Reviews Endocrinology, 2017 - nature.com
The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous
and lipid environments, subserves an array of functions in the mammalian central nervous …
and lipid environments, subserves an array of functions in the mammalian central nervous …
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation
D Brites - Frontiers in pharmacology, 2012 - frontiersin.org
Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …
Although generally harmless, some neonates may develop very high levels of unconjugated …
An updated view of hypothalamic–vascular–pituitary unit function and plasticity
The discoveries of novel functional adaptations of the hypothalamus and anterior pituitary
gland for physiological regulation have transformed our understanding of their interaction …
gland for physiological regulation have transformed our understanding of their interaction …
Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons
Background The maturation of the hypothalamic-pituitary-gonadal (HPG) axis is crucial for
the establishment of reproductive function. In female mice, neuronal nitric oxide synthase …
the establishment of reproductive function. In female mice, neuronal nitric oxide synthase …
Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction
N Bellefontaine, K Chachlaki, J Parkash… - The Journal of …, 2014 - Am Soc Clin Investig
The transition to puberty and adult fertility both require a minimum level of energy
availability. The adipocyte-derived hormone leptin signals the long-term status of peripheral …
availability. The adipocyte-derived hormone leptin signals the long-term status of peripheral …
Hypothalamic Kisspeptin neurons: integral elements of the GnRH system
V Prashar, T Arora, R Singh, A Sharma… - Reproductive …, 2023 - Springer
Highly sophisticated and synchronized interactions of various cells and hormonal signals
are required to make organisms competent for reproduction. GnRH neurons act as a …
are required to make organisms competent for reproduction. GnRH neurons act as a …
Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation
Reproduction is controlled in the brain by a neural network that drives the secretion of
gonadotropin-releasing hormone (GnRH). Various permissive homeostatic signals must be …
gonadotropin-releasing hormone (GnRH). Various permissive homeostatic signals must be …
Neuroanatomical framework of the metabolic control of reproduction
JW Hill, CF Elias - Physiological reviews, 2018 - journals.physiology.org
A minimum amount of energy is required for basic physiological processes, such as protein
biosynthesis, thermoregulation, locomotion, cardiovascular function, and digestion …
biosynthesis, thermoregulation, locomotion, cardiovascular function, and digestion …