The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Organoid models have the potential to recapitulate the biological and pharmacotypic
features of parental tumors. Nevertheless, integrative pharmaco-proteogenomics analysis …

Neutrophils are cells at the frontline of innate immunity that can quickly activate effector
functions to eliminate pathogens upon stimulation. However, little is known about the …

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and
intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role …

The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective
and metabolic genes in response to various stress inputs to restore cellular homeostasis …

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell
growth and facilitate tumor development. Glucose and glutamine in the TME are essential for …

Lung adenocarcinoma (LUAD) is the most common type of lung cancer which accounts for
about 40% of all lung cancers. Early detection, risk stratification and treatment are important …