The diagnosis and treatment of prostate cancer: a review
Importance Prostate cancer is the most common cancer diagnosis made in men with more
than 160 000 new cases each year in the United States. Although it often has an indolent …
than 160 000 new cases each year in the United States. Although it often has an indolent …
Radiotheranostics: a roadmap for future development
Radiotheranostics, injectable radiopharmaceuticals with antitumour effects, have seen rapid
development over the past decade. Although some formulations are already approved for …
development over the past decade. Although some formulations are already approved for …
Comparison of universal genetic testing vs guideline-directed targeted testing for patients with hereditary cancer syndrome
NJ Samadder, D Riegert-Johnson, L Boardman… - JAMA …, 2021 - jamanetwork.com
Importance Hereditary factors play a key role in the risk of develo** several cancers.
Identification of a germline predisposition can have important implications for treatment …
Identification of a germline predisposition can have important implications for treatment …
Inherited DNA-repair gene mutations in men with metastatic prostate cancer
Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
[HTML][HTML] Widespread and functional RNA circularization in localized prostate cancer
The cancer transcriptome is remarkably complex, including low-abundance transcripts,
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
Limited versus extended pelvic lymph node dissection for prostate cancer: a randomized clinical trial
KA Touijer, DD Sjoberg, N Benfante… - European urology …, 2021 - Elsevier
Background Pelvic lymph node dissection (PLND) is the most reliable procedure for lymph
node staging. However, the therapeutic benefit remains unproven; although most radical …
node staging. However, the therapeutic benefit remains unproven; although most radical …
The association between germline BRCA2 variants and sensitivity to platinum‐based chemotherapy among men with metastatic prostate cancer
BACKGROUND Breast cancer 2 (BRCA2)‐associated breast and ovarian cancers are
sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated …
sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated …
Genomic markers in prostate cancer decision making
V Cucchiara, MR Cooperberg, M Dall'Era, DW Lin… - European urology, 2018 - Elsevier
Context Although the widespread use of prostate-specific antigen (PSA) has led to an early
detection of prostate cancer (PCa) and a reduction of metastatic disease at diagnosis, PSA …
detection of prostate cancer (PCa) and a reduction of metastatic disease at diagnosis, PSA …
Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations
The oligometastatic state has been proposed as an intermediate stage of cancer spread
between localized disease and widespread metastases. With improvements in diagnostic …
between localized disease and widespread metastases. With improvements in diagnostic …
Increasing incidence of metastatic prostate cancer in the United States (2004–2013)
Background: Changes in prostate cancer screening practices in the United States have led
to recent declines in overall incidence, but it is unknown whether relaxed screening has led …
to recent declines in overall incidence, but it is unknown whether relaxed screening has led …