PINTology: A short history of the lncRNA LINC‐PINT in different diseases
LINC‐PINT is a p53‐induced long intergenic noncoding transcript that plays a crucial role in
many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in …
many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in …
Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects
Ö İş, Y Min, X Wang, SR Oatman, A Abraham Daniel… - Glia, 2025 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐
layered complexity in its molecular etiology. Multiple omics‐based approaches, such as …
layered complexity in its molecular etiology. Multiple omics‐based approaches, such as …
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Genome-wide association studies (GWAS) have identified> 80 Alzheimer's disease and
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
Interindividual variation in human cortical cell type abundance and expression
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types
from small postmortem cohorts. We extended these efforts by assessing cell type variation …
from small postmortem cohorts. We extended these efforts by assessing cell type variation …
Genetic Determinants of Vascular Dementia
Vascular dementia (VaD) is a prevalent form of cognitive impairment with underlying
vascular etiology. In this review, we examine recent genetic advancements in our …
vascular etiology. In this review, we examine recent genetic advancements in our …
Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease
SE Heuer, KJ Keezer, AA Hewes… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Human data suggest susceptibility and resilience to features of Alzheimer's
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
Cell-specific transcriptional signatures of vascular cells in Alzheimer's disease: perspectives, pathways, and therapeutic directions
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is marked by
profound neurovascular dysfunction and significant cell-specific alterations in the brain …
profound neurovascular dysfunction and significant cell-specific alterations in the brain …
Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium
Inflammation biomarkers can provide valuable insight into the role of inflammatory
processes in many diseases and conditions. Sequencing based analyses of such …
processes in many diseases and conditions. Sequencing based analyses of such …
The big picture of neurodegeneration: a meta study to extract the essential evidence on neurodegenerative diseases in a network-based approach
The common features of all neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease, are the …
Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease, are the …
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins
Background Alzheimer's disease (AD) is neuropathologically characterized by amyloid-beta
(Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks …
(Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks …