DNA double-strand breaks as drivers of neural genomic change, function, and disease
FW Alt, B Schwer - DNA repair, 2018 - Elsevier
Early work from about two decades ago implicated DNA double-strand break (DSB)
formation and repair in neuronal development. Findings emerging from recent studies of …
formation and repair in neuronal development. Findings emerging from recent studies of …
V (D) J recombination: recent insights in formation of the recombinase complex and recruitment of DNA repair machinery
SM Christie, C Fijen, E Rothenberg - Frontiers in Cell and …, 2022 - frontiersin.org
V (D) J recombination is an essential mechanism of the adaptive immune system, producing
a diverse set of antigen receptors in develo** lymphocytes via regulated double strand …
a diverse set of antigen receptors in develo** lymphocytes via regulated double strand …
The fundamental role of chromatin loop extrusion in physiological V (D) J recombination
The RAG endonuclease initiates Igh V (D) J assembly in B cell progenitors by joining D
segments to JH segments, before joining upstream VH segments to DJH intermediates. In …
segments to JH segments, before joining upstream VH segments to DJH intermediates. In …
CTCF orchestrates long-range cohesin-driven V (D) J recombinational scanning
The RAG endonuclease initiates Igh locus V (D) J recombination in progenitor (pro)-B cells.
Upon binding a recombination centre-based JH, RAG scans upstream chromatin via loop …
Upon binding a recombination centre-based JH, RAG scans upstream chromatin via loop …
CTCF-binding elements mediate accessibility of RAG substrates during chromatin scanning
RAG endonuclease initiates antibody heavy chain variable region exon assembly from V, D,
and J segments within a chromosomal V (D) J recombination center (RC) by cleaving …
and J segments within a chromosomal V (D) J recombination center (RC) by cleaving …
[HTML][HTML] Epigenetic and transcriptional mechanisms for the regulation of IL-10
IL-10 is a critical immunoregulatory cytokine expressed in virtually all immune cell types.
Maintaining a delicate balance between effective immune response and tolerance requires …
Maintaining a delicate balance between effective immune response and tolerance requires …
RAG chromatin scanning during V (D) J recombination and chromatin loop extrusion are related processes
An effective adaptive immune system depends on the ability of develo** B and T cells to
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …
Ku70 suppresses alternative end joining in G1-arrested progenitor B cells
Z Liang, V Kumar, M Le Bouteiller… - Proceedings of the …, 2021 - National Acad Sciences
Classical nonhomologous end joining (C-NHEJ) repairs DNA double-strand breaks (DSBs)
throughout interphase but predominates in G1 phase when homologous recombination is …
throughout interphase but predominates in G1 phase when homologous recombination is …
ATM and 53BP1 regulate alternative end joining–mediated V (D) J recombination
G0-G1 phase alternative end joining (A-EJ) is a recently defined mutagenic pathway
characterized by resected deletion and translocation joints that are predominantly direct and …
characterized by resected deletion and translocation joints that are predominantly direct and …
Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus
The thymus is the primary lymphoid organ where naïve T cells are generated; however, with
the exception of age, the parameters that govern its function in healthy humans remain …
the exception of age, the parameters that govern its function in healthy humans remain …