Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

K Tsutsui, GE Bentley, G Bedecarrats, T Osugi… - Frontiers in …, 2010 - Elsevier
Identification of novel neurohormones that regulate the reproductive axis is essential for the
progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) …

A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary

S Whirledge, JA Cidlowski - Endocrinology, 2013 - academic.oup.com
In addition to the well-characterized role of the sex steroid receptors in regulating fertility and
reproduction, reproductive events are also mediated by the hypothalamic-pituitary-adrenal …

Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals

LJ Kriegsfeld, DF Mei, GE Bentley… - Proceedings of the …, 2006 - National Acad Sciences
Successful reproduction requires maintenance of the reproductive axis within fine operating
limits through negative feedback actions of sex steroids. Despite the importance of this …

[書籍][B] Physiological adaptations for breeding in birds

TD Williams - 2012 - books.google.com
Physiological Adaptations for Breeding in Birds is the most current and comprehensive
account of research on avian reproduction. It develops two unique themes: the consideration …

Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone

T Ubuka, K Inoue, Y Fukuda, T Mizuno, K Ukena… - …, 2012 - academic.oup.com
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits
gonadotropin secretion in birds and mammals. To further understand its physiological roles …

Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion

IJ Clarke, IP Sari, Y Qi, JT Smith, HC Parkington… - …, 2008 - academic.oup.com
We identified a gene in the ovine hypothalamus encoding for RFamide-related peptide-3
(RFRP-3), and tested the hypothesis that this system produces a hypophysiotropic hormone …

Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis

T Ubuka, K Morgan, AJ Pawson, T Osugi… - PloS one, 2009 - journals.plos.org
The existence of a hypothalamic gonadotropin-inhibiting system has been elusive. A
neuropeptide named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH2) which …

Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail

T Ubuka, K Ukena, PJ Sharp, GE Bentley… - …, 2006 - academic.oup.com
Until recently, any neuropeptide that directly inhibits gonadotropin secretion had not been
identified. We recently identified a novel hypothalamic dodecapeptide that directly inhibits …

Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and-II neurons in European starling brain

T Ubuka, S Kim, Y Huang, J Reid, J Jiang… - …, 2008 - academic.oup.com
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic dodecapeptide (SIKPSAYLPLRF-
NH2) that directly inhibits gonadotropin synthesis and release from quail pituitary. The action …

[PDF][PDF] Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats

M Murakami, T Matsuzaki, T Iwasa, T Yasui… - Journal of …, 2008 - Citeseer
Abstract Gonadotropin-inhibitory hormone (GnIH), a newly discovered hypothalamic
RFamide peptide, inhibits reproductive activity by decreasing gonadotropin synthesis and …