Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies

LHM Geraldo, TCLS Spohr, RF Amaral… - Signal transduction and …, 2021 - nature.com
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Lysophospholipid mediators in health and disease

K Kano, J Aoki, T Hla - Annual Review of Pathology …, 2022 - annualreviews.org
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

[HTML][HTML] LPA receptor signaling: pharmacology, physiology, and pathophysiology

YC Yung, NC Stoddard, J Chun - Journal of lipid research, 2014 - Elsevier
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2

RG Pertwee, AC Howlett, ME Abood… - Pharmacological …, 2010 - Elsevier
There are at least two types of cannabinoid receptors (CB 1 and CB 2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ 9 …

The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

LPA receptors: subtypes and biological actions

JW Choi, DR Herr, K Noguchi, YC Yung… - Annual review of …, 2010 - annualreviews.org
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Y Kihara, M Maceyka, S Spiegel… - British journal of …, 2014 - Wiley Online Library
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

AP Davenport, SPH Alexander, JL Sharman… - Pharmacological …, 2013 - Elsevier
Abstract In 2005, the International Union of Basic and Clinical Pharmacology Committee on
Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of …

Lysophosphatidic acid signaling in the nervous system

YC Yung, NC Stoddard, H Mirendil, J Chun - Neuron, 2015 - cell.com
The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and …

A Yamashita, Y Hayashi, Y Nemoto-Sasaki, M Ito… - Progress in lipid …, 2014 - Elsevier
Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …