Eicosanoids and cancer
D Wang, RN DuBois - Nature Reviews Cancer, 2010 - nature.com
Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …
have been implicated in various pathological processes, such as inflammation and cancer …
Mechanisms and consequences of dendritic cell migration
Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are
strategically positioned as immune sentinels poised to respond to invading pathogens in …
strategically positioned as immune sentinels poised to respond to invading pathogens in …
Chemokine and chemotactic signals in dendritic cell migration
Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation
of specific T-cell responses and for the development of immune tolerance. Immature DCs …
of specific T-cell responses and for the development of immune tolerance. Immature DCs …
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
BACKGROUND: Leukotrienes (LTs) are potent proinflammatory lipid mediators with key
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes) …
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes) …
Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation
CD Sadik, AD Luster - Journal of leukocyte biology, 2012 - academic.oup.com
Chemoattractants are pivotal mediators of host defense, orchestrating the recruitment of
immune cells into sites of infection and inflammation. Chemoattractants display vast …
immune cells into sites of infection and inflammation. Chemoattractants display vast …
CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
K Kabashima, N Shiraishi, K Sugita, T Mori… - The American journal of …, 2007 - Elsevier
CCR7 is regarded as an essential chemokine receptor for cutaneous dendritic cell (DC)
migration into the regional lymph nodes. However, complete migratory inhibition cannot be …
migration into the regional lymph nodes. However, complete migratory inhibition cannot be …
The role of the LTB4-BLT1 axis in health and disease
R He, Y Chen, Q Cai - Pharmacological research, 2020 - Elsevier
Abstract Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated
from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase …
from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase …
Leukotrienes in tumor-associated inflammation
Leukotrienes are biologically active eicosanoid lipid mediators that originate from oxidative
metabolism of arachidonic acid. Biosynthesis of leukotrienes involves a set of soluble and …
metabolism of arachidonic acid. Biosynthesis of leukotrienes involves a set of soluble and …
Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19
Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is
important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21 …
important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21 …
The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells
Dendritic cell (DC) maturation and migration are events critical for the initiation of immune
responses. After encountering pathogens, DCs upregulate the expression of costimulatory …
responses. After encountering pathogens, DCs upregulate the expression of costimulatory …