Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

L Galluzzi, JM Bravo-San Pedro, B Levine… - Nature reviews Drug …, 2017 - nature.com
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

Aspergillus fumigatus morphology and dynamic host interactions

FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

K Cadwell - Nature Reviews Immunology, 2016 - nature.com
Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

Autophagy and inflammation

Y Matsuzawa-Ishimoto, S Hwang… - Annual review of …, 2018 - annualreviews.org
The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy

KM Hooper, E Jacquin, T Li, JM Goodwin… - Journal of Cell …, 2022 - rupress.org
Non-canonical autophagy is a key cellular pathway in immunity, cancer, and
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …

Pathogenic fungal infection in the lung

Z Li, G Lu, G Meng - Frontiers in immunology, 2019 - frontiersin.org
Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

The Cell Wall of the Human Fungal Pathogen Aspergillus fumigatus: Biosynthesis, Organization, Immune Response, and Virulence

JP Latgé, A Beauvais, G Chamilos - Annual review of …, 2017 - annualreviews.org
More than 90% of the cell wall of the filamentous fungus Aspergillus fumigatus comprises
polysaccharides. Biosynthesis of the cell wall polysaccharides is under the control of three …

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

MHT Stappers, AE Clark, V Aimanianda, S Bidula… - Nature, 2018 - nature.com
Resistance to infection is critically dependent on the ability of pattern recognition receptors
to recognize microbial invasion and induce protective immune responses. One such family …