Immune responses to human fungal pathogens and therapeutic prospects
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
Aspergillus fumigatus and Aspergillosis in 2019
JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …
and pathological situations. Accordingly, alterations in autophagy have been linked to …
Aspergillus fumigatus morphology and dynamic host interactions
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …
disease in immunocompromised individuals. The interactions between A. fumigatus and the …
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
K Cadwell - Nature Reviews Immunology, 2016 - nature.com
Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …
coordination of complex multicellular immune responses. The successful resolution of …
Autophagy and inflammation
Y Matsuzawa-Ishimoto, S Hwang… - Annual review of …, 2018 - annualreviews.org
The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …
we review the function of autophagy and autophagy proteins in inflammation. We discuss …
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy
KM Hooper, E Jacquin, T Li, JM Goodwin… - Journal of Cell …, 2022 - rupress.org
Non-canonical autophagy is a key cellular pathway in immunity, cancer, and
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …
Pathogenic fungal infection in the lung
Z Li, G Lu, G Meng - Frontiers in immunology, 2019 - frontiersin.org
Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …
The Cell Wall of the Human Fungal Pathogen Aspergillus fumigatus: Biosynthesis, Organization, Immune Response, and Virulence
JP Latgé, A Beauvais, G Chamilos - Annual review of …, 2017 - annualreviews.org
More than 90% of the cell wall of the filamentous fungus Aspergillus fumigatus comprises
polysaccharides. Biosynthesis of the cell wall polysaccharides is under the control of three …
polysaccharides. Biosynthesis of the cell wall polysaccharides is under the control of three …
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus
Resistance to infection is critically dependent on the ability of pattern recognition receptors
to recognize microbial invasion and induce protective immune responses. One such family …
to recognize microbial invasion and induce protective immune responses. One such family …