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From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …
a small number of genes and thereby molecular mechanisms have been discovered …
[PDF][PDF] Natural genetic variation as a tool for discovery in Caenorhabditis nematodes
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …
R/qtl2: software for map** quantitative trait loci with high-dimensional data and multiparent populations
R/qtl2 is an interactive software environment for map** quantitative trait loci (QTL) in
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution
Red Queen dynamics, involving coevolutionary interactions between species, are
ubiquitous, sha** the evolution of diverse biological systems. To date, information on the …
ubiquitous, sha** the evolution of diverse biological systems. To date, information on the …
Environmental radiation exposure at Chornobyl has not systematically affected the genomes or chemical mutagen tolerance phenotypes of local worms
SC Tintori, D Çağlar, P Ortiz, I Chyzhevskyi… - Proceedings of the …, 2024 - pnas.org
The 1986 disaster at the Chornobyl Nuclear Power Plant transformed the surrounding
region into the most radioactive landscape known on the planet. Whether or not this sudden …
region into the most radioactive landscape known on the planet. Whether or not this sudden …
[PDF][PDF] Evaluating the power and limitations of genome-wide association studies in Caenorhabditis elegans
Quantitative genetics in Caenorhabditis elegans seeks to identify naturally segregating
genetic variants that underlie complex traits. Genome-wide association studies scan the …
genetic variants that underlie complex traits. Genome-wide association studies scan the …
Detecting the genomic signal of polygenic adaptation and the role of epistasis in evolution
Over the last decade, the genomic revolution has offered the possibility to generate
tremendous amounts of data that contain valuable information on the genetic basis of …
tremendous amounts of data that contain valuable information on the genetic basis of …
Genome‐wide association and environmental suppression of the mortal germline phenotype of wild C. elegans
The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population
GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
Selection can favor a recombination landscape that limits polygenic adaptation
Modifiers of recombination rates have been described but the selective pressures acting on
them and their effect on adaptation to novel environments remain unclear. We performed …
them and their effect on adaptation to novel environments remain unclear. We performed …