From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation

KS Evans, MH van Wijk, PT McGrath, EC Andersen… - Trends in Genetics, 2021 - cell.com
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …

[PDF][PDF] Natural genetic variation as a tool for discovery in Caenorhabditis nematodes

EC Andersen, MV Rockman - Genetics, 2022 - academic.oup.com
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

R/qtl2: software for map** quantitative trait loci with high-dimensional data and multiparent populations

KW Broman, DM Gatti, P Simecek, NA Furlotte… - Genetics, 2019 - academic.oup.com
R/qtl2 is an interactive software environment for map** quantitative trait loci (QTL) in
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …

The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution

A Papkou, T Guzella, W Yang, S Koepper… - Proceedings of the …, 2019 - pnas.org
Red Queen dynamics, involving coevolutionary interactions between species, are
ubiquitous, sha** the evolution of diverse biological systems. To date, information on the …

Environmental radiation exposure at Chornobyl has not systematically affected the genomes or chemical mutagen tolerance phenotypes of local worms

SC Tintori, D Çağlar, P Ortiz, I Chyzhevskyi… - Proceedings of the …, 2024 - pnas.org
The 1986 disaster at the Chornobyl Nuclear Power Plant transformed the surrounding
region into the most radioactive landscape known on the planet. Whether or not this sudden …

[PDF][PDF] Evaluating the power and limitations of genome-wide association studies in Caenorhabditis elegans

SJ Widmayer, KS Evans, S Zdraljevic, EC Andersen - G3, 2022 - academic.oup.com
Quantitative genetics in Caenorhabditis elegans seeks to identify naturally segregating
genetic variants that underlie complex traits. Genome-wide association studies scan the …

Detecting the genomic signal of polygenic adaptation and the role of epistasis in evolution

K Csilléry, A Rodríguez‐Verdugo, C Rellstab… - Molecular …, 2018 - Wiley Online Library
Over the last decade, the genomic revolution has offered the possibility to generate
tremendous amounts of data that contain valuable information on the genetic basis of …

Genome‐wide association and environmental suppression of the mortal germline phenotype of wild C. elegans

L Frézal, M Saglio, G Zhang, L Noble, A Richaud… - EMBO …, 2023 - embopress.org
The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

Selection can favor a recombination landscape that limits polygenic adaptation

T Parée, L Noble, D Roze… - Molecular Biology and …, 2025 - academic.oup.com
Modifiers of recombination rates have been described but the selective pressures acting on
them and their effect on adaptation to novel environments remain unclear. We performed …