Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

A main determinant of the spatial resolution of live-cell super-resolution (SR) microscopes is
the maximum photon flux that can be collected. To further increase the effective resolution …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

The classic mode of STING activation is through binding the cyclic dinucleotide 2′ 3′-
cyclic GMP–AMP (cGAMP), produced by the DNA sensor cyclic GMP–AMP synthase …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between
both organelles, but their role in normal and diseased human neurons remains unknown. In …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …