Diabetes mellitus, energy metabolism, and COVID-19

C Conte, E Cipponeri, M Roden - Endocrine Reviews, 2024 - academic.oup.com
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

The role and intervention of mitochondrial metabolism in osteoarthritis

Z Qi, J Zhu, W Cai, C Lou, Z Li - Molecular and cellular biochemistry, 2024 - Springer
Osteoarthritis (OA), a prevalent degenerative joint disease, affects a substantial global
population. Despite the elusive etiology of OA, recent investigations have implicated …

Mitochondrial antioxidants abate SARS-COV-2 pathology in mice

JW Guarnieri, T Lie, YES Albrecht, P Hewin… - Proceedings of the …, 2024 - pnas.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection inhibits
mitochondrial oxidative phosphorylation (OXPHOS) and elevates mitochondrial reactive …

SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19

JW Guarnieri, JA Haltom, YES Albrecht, T Lie… - Pharmacological …, 2024 - Elsevier
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an
exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection …

Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia

L Ye, Y Gao, SWF Mok, W Liao, Y Wang… - Journal of …, 2024 - Springer
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized
by overexuberant inflammatory responses and inefficient pathogens-containing, the two …

Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection

T Zhang, Y Li, L Pan, J Sha, M Bailey, E Faure-Kumar… - Nature Aging, 2024 - nature.com
Understanding the pathophysiology of neurological symptoms observed after severe acute
respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing …

Differentially‐regulated miRNAs in COVID‐19: A systematic review

W Ahmad, B Gull, J Baby, NG Panicker… - Reviews in Medical …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is responsible for
coronavirus disease of 2019 (COVID‐19) that infected more than 760 million people …

Insulin sensitizers in 2023: lessons learned and new avenues for investigation

JR Colca, SP Tanis, RF Kletzien… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction 'Insulin sensitizers' derived discoveries of the Takeda Company in 1970s.
Pioglitazone remains the best in class with beneficial pleiotropic pharmacology, although …

Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches

L Nuyttens, J Vandewalle, C Libert - EMBO Molecular Medicine, 2024 - embopress.org
Sepsis is a heterogeneous syndrome resulting from a dysregulated host response to
infection. It is considered as a global major health priority. Sepsis is characterized by …

[HTML][HTML] Increased prevalence of cardiovascular-kidney-metabolic syndrome during COVID-19: A propensity score-matched study

V Trimarco, R Izzo, D Pacella, MV Manzi… - Diabetes Research and …, 2024 - Elsevier
A recent presidential advisory from the American Heart Association (AHA) has introduced
the term cardiovascular-kidney-metabolic (CKM) syndrome to describe the complex …