PP2A as a master regulator of the cell cycle
N Wlodarchak, Y **ng - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Histone phosphorylation: a chromatin modification involved in diverse nuclear events
D Rossetto, N Avvakumov, J Côté - Epigenetics, 2012 - Taylor & Francis
Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …
modulate chromatin structure. These marks function as signals during various chromatin …
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
C Adriaens, L Standaert, J Barra, M Latil, A Verfaillie… - Nature medicine, 2016 - nature.com
In a search for mediators of the p53 tumor suppressor pathway, which induces pleiotropic
and often antagonistic cellular responses, we identified the long noncoding RNA (lncRNA) …
and often antagonistic cellular responses, we identified the long noncoding RNA (lncRNA) …
Histone H2AX phosphorylation: a marker for DNA damage
The DNA damage response can be initiated in response to a variety of stress signals that
are encountered during physiological processes or in response to exogenous cues, such as …
are encountered during physiological processes or in response to exogenous cues, such as …
γH2AX: a sensitive molecular marker of DNA damage and repair
LJ Mah, A El-Osta, TC Karagiannis - Leukemia, 2010 - nature.com
Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …
early cellular response to the induction of DNA double-strand breaks. Detection of this …
[HTML][HTML] The human papillomavirus (HPV)-related cancer biology: An overview
RP Araldi, TA Sant'Ana, DG Módolo, TC de Melo… - Biomedicine & …, 2018 - Elsevier
Despite the novel diagnostic methods and therapies implemented in oncology, the number
of patients that succumb by the cancer remains high globally. Currently studies point out that …
of patients that succumb by the cancer remains high globally. Currently studies point out that …
The same, only different–DNA damage checkpoints and their reversal throughout the cell cycle
IA Shaltiel, L Krenning, W Bruinsma… - Journal of cell …, 2015 - journals.biologists.com
Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
γ-H2AX-a novel biomarker for DNA double-strand breaks
LJ Kuo, LX Yang - In vivo, 2008 - iv.iiarjournals.org
When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks
(DSBs), it is always followed by the phosphorylation of the histone, H2AX. H2AX is a variant …
(DSBs), it is always followed by the phosphorylation of the histone, H2AX. H2AX is a variant …
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
A Kinner, W Wu, C Staudt, G Iliakis - Nucleic acids research, 2008 - academic.oup.com
DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …
consequences for cell survival and the maintenance of genomic stability. In higher …