Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

The incorporation of deuterium in organic molecules has widespread applications in
medicinal chemistry and materials science,. For example, the deuterated drugs austedo …

The aryl O-carbamate (ArOAm) group is among the strongest of the directed metalation
groups (DMGs) in directed ortho metalation (D o M) chemistry, especially in the form Ar …

The importance of deuterium labelling in a variety of applications, ranging from mechanistic
studies to drug‐discovery, has spurred immense interest in the development of new …

The pharmacokinetics of pharmaceutical drugs can be improved by replacing C− H bonds
with the more stable C− D bonds at the α‐position to heteroatoms, which is a typical …

Precise deuterium incorporation of bioactive molecules is highly desirable in order to
improve ADME properties and monitor pharmacokinetics. Organic electrochemistry offers a …

This review explores the diverse applications of deuterium in medicinal chemistry,
particularly as an analytical tool in mass spectrometry. Deuterium applications extend …

Over the past years our lab has established a research program towards the late-stage
introduction of deuterium into organic molecules using Pd-catalyzed reversible C–H …

Nirmatrelvir and GC373 inhibit the SARS-CoV-2 3CL protease and hinder viral replication in
COVID-19. As nirmatrelvir in Paxlovid is oxidized by cytochrome P450 3A4, ritonavir is …

Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting
a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and …