Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Studies of the administration of interleukin-2 to patients with metastatic melanoma or kidney
cancer have shown that immunological manipulations can mediate the durable regression …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC) …

Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Tumor-associated, MHC-restricted peptides, recognized by tumor-specific CD8+
lymphocytes, are desirable targets for novel approaches in immunotherapy because of their …

The immune system is a complex arrangement of cells and molecules that preserve the
integrity of the organism by elimination of all elements judged dangerous. Within the …

Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of
cancer-related death. The biological process of HCC is complex, with multiple factors …

Many antigens recognized by autologous T lymphocytes have been identified on human
melanoma. Melanoma patients usually mount a spontaneous T cell response against their …

Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …