Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Understanding protein non-folding
This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
Modeling aspects of the language of life through transfer-learning protein sequences
Background Predicting protein function and structure from sequence is one important
challenge for computational biology. For 26 years, most state-of-the-art approaches …
challenge for computational biology. For 26 years, most state-of-the-art approaches …
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids
Protein intrinsic disorder is becoming increasingly recognized in proteomics research. While
lacking structure, many regions of disorder have been associated with biological function …
lacking structure, many regions of disorder have been associated with biological function …
Tau protein disrupts nucleocytoplasmic transport in Alzheimer's disease
Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …
[HTML][HTML] WNK kinases sense molecular crowding and rescue cell volume via phase separation
When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …
Length-dependent prediction of protein intrinsic disorder
Background Due to the functional importance of intrinsically disordered proteins or protein
regions, prediction of intrinsic protein disorder from amino acid sequence has become an …
regions, prediction of intrinsic protein disorder from amino acid sequence has become an …
Rapid prediction and analysis of protein intrinsic disorder
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …
To achieve this coordination, each participant must have a valid identification (ID) that is …
Intrinsic disorder in transcription factors
Intrinsic disorder (ID) is highly abundant in eukaryotes, which reflect the greater need for
disorder-associated signaling and transcriptional regulation in nucleated cells. Although …
disorder-associated signaling and transcriptional regulation in nucleated cells. Although …