Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …

Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It
plays a crucial role in various metabolic pathways, inflammation processes, stress response …

Background Predicting protein function and structure from sequence is one important
challenge for computational biology. For 26 years, most state-of-the-art approaches …

Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …

Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Methylation of N6-adenosine (m6A) in mRNA is an important posttranscriptional gene
regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins …

It's widely appreciated that liquid–liquid phase separation (LLPS) underlies the formation of
membraneless organelles, which function to concentrate proteins and nucleic acids. In the …

Motivation Capturing long-range interactions between structural but not sequence neighbors
of proteins is a long-standing challenging problem in bioinformatics. Recently, long short …

Protein intrinsic disorder is becoming increasingly recognized in proteomics research. While
lacking structure, many regions of disorder have been associated with biological function …