Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

Given its manifold potential therapeutic applications and amenability to modification,
noscapine is a veritable “Renaissance drug” worthy of commemoration. Perhaps the only …

Noscapine is a phthalideisoquinoline alkaloid, which represents a class of plant specialized
metabolites within the large and structurally diverse group of benzylisoquinoline alkaloids …

The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses …

Noscapine is a natural alkaloid that is used as an antitussive medicine. However, it also acts
as a weak anticancer agent in certain in vivo models through a mechanism that is largely …

Liquid chromatography–mass spectrometry (LC–MS)-based metabolomics can have a
major impact in multiple research fields, especially when combined with other technologies …

Noscapine is a phthalide isoquinoline alkaloid that easily traverses the blood brain barrier
and has been used for years as an antitussive agent with high safety. Despite binding opioid …

We have characterized four sequential enzymes that transform 1-hydroxy-N-methylcanadine
to narcotoline hemiacetal, completing our elucidation of noscapine biosynthesis in opium …

Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They are used
as food and to produce edible oil. The opium poppy plant contains narcotic alkaloids such …

Cytochrome P450 enzymes (P450s) play a critical role in drug metabolism, with the CYP3A
subfamily being responsible for the biotransformation of over 50% of marked drugs. While …