Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and
inflammation is a centrally important hallmark,,,,,–. Here we examined whether IL-11, a pro …

Sympathetic innervation is essential for the development of functional beige fat that
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …

Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy
metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is …

The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …

Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …

Defects in adipocyte lipolysis drive multiple aspects of cardiometabolic disease, but the
transcriptional framework controlling this process has not been established. To address this …

Lipid droplets (LDs), once considered mere storage depots for lipids, have gained
recognition for their intricate roles in cellular processes, including metabolism, membrane …