The COVID-19 pandemic now totaling 13,000,000 cases and over 571,000 deaths has
continued to teach the medical, scientific and lay communities about viral infectious disease …

Background Trauma‐induced hypocalcemia is an underappreciated complication of severe
injury but is well known to result in the derangement of an array of physiological regulatory …

BACKGROUND: Neutrophil extracellular traps (NETs) are composed of DNA, enzymes, and
citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs …

Abstract Coronavirus disease 19 (COVID-19) presents with disease severities of varying
degree. In its most severe form, infection may lead to respiratory failure and multi-organ …

Endothelial cells line all blood vessels and are critical regulators of vascular tone. In
hypertension, disruption of endothelial function alters the release of endothelial-derived …

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) had spread from
China and, within 2 months, became a global pandemic. The infection from this disease can …

The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and
regulate gene expression within the nucleus. Evidence collected mainly from the peripheral …

Idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases
characterized by immune-mediated muscle injury. Abnormal neutrophil extracellular traps …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …

Acute hemorrhage commonly leads to coagulopathy and organ dysfunction or failure.
Recent evidence suggests that damage to the endothelial glycocalyx contributes to these …