CNS infection and immune privilege
Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …
responses to challenge by alloantigen. However, the CNS does show local inflammation in …
Toll-like receptor signaling in the establishment and function of the immune system
Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the
development and function of the immune system. TLR signaling promotes the earliest …
development and function of the immune system. TLR signaling promotes the earliest …
Severe influenza pneumonitis in children with inherited TLR3 deficiency
HK Lim, SXL Huang, J Chen, G Kerner… - Journal of Experimental …, 2019 - rupress.org
Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review
A Elhabyan, S Elyaacoub, E Sanad, A Abukhadra… - Virus research, 2020 - Elsevier
Background Susceptibility to severe viral infections was reported to be associated with
genetic variants in immune response genes using case reports and GWAS studies. SARS …
genetic variants in immune response genes using case reports and GWAS studies. SARS …
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons
Human herpes simplex virus 1 (HSV-1) encephalitis can be caused by inborn errors of the
TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity. Deficiencies …
TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity. Deficiencies …
Neurologic complications in herpes simplex encephalitis: clinical, immunological and genetic studies
T Armangué, G Olivé-Cirera, E Martínez-Hernandez… - Brain, 2023 - academic.oup.com
Patients with herpes simplex virus (HSV) encephalitis (HSE) often develop neuronal
autoantibody-associated encephalitis (AE) post-infection. Risk factors of AE are unknown …
autoantibody-associated encephalitis (AE) post-infection. Risk factors of AE are unknown …
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain
Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained,.
Here, we report on two unrelated people who had HSE as children and are homozygous for …
Here, we report on two unrelated people who had HSE as children and are homozygous for …
Functional IRF3 deficiency in a patient with herpes simplex encephalitis
LL Andersen, N Mørk, LS Reinert… - Journal of Experimental …, 2015 - rupress.org
Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I
interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel …
interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel …
Herpes simplex encephalitis: an update
JW Gnann, RJ Whitley - Current infectious disease reports, 2017 - Springer
Abstract Purpose of Review The goal of this review is to provide an update on current
thinking regarding herpes simplex encephalitis (HSE), emphasizing new information about …
thinking regarding herpes simplex encephalitis (HSE), emphasizing new information about …
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis
Abstract Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn
errors of TLR3-and DBR1-mediated central nervous system cell-intrinsic immunity can …
errors of TLR3-and DBR1-mediated central nervous system cell-intrinsic immunity can …