Targeting CDK1 in cancer: mechanisms and implications
Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …
promising candidate targets for cancer treatment. These proteins complexed with cyclins …
Wnt signaling in triple-negative breast cancer
Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …
Mediated nuclear import and export of TAZ and the underlying molecular requirements
Nucleocytoplasmic distribution of Yap/TAZ is regulated by the Hippo pathway and the
cytoskeleton. While interactions with cytosolic and nuclear “retention factors”(14–3–3 and …
cytoskeleton. While interactions with cytosolic and nuclear “retention factors”(14–3–3 and …
The hippo signaling pathway in cancer: a cell cycle perspective
Simple Summary Cancer is increasingly viewed as a cell cycle disease in that the
dysregulation of the cell cycle machinery is a common feature in cancer. The Hippo …
dysregulation of the cell cycle machinery is a common feature in cancer. The Hippo …
[HTML][HTML] Transcriptional co-activators YAP/TAZ: Potential therapeutic targets for metastatic breast cancer
W Zhao, M Wang, M Cai, C Zhang, Y Qiu… - Biomedicine & …, 2021 - Elsevier
Breast cancer is the most commonly diagnosed cancer among women. Although routine and
targeted therapies have improved the survival rate, there are still considerable challenges in …
targeted therapies have improved the survival rate, there are still considerable challenges in …
Yes-associated protein and transcriptional coactivator with PDZ-binding motif as new targets in cardiovascular diseases
Y Yu, X Su, Q Qin, Y Hou, X Zhang, H Zhang… - Pharmacological …, 2020 - Elsevier
As transcriptional co-activators, Yes-associated protein (YAP) and transcriptional coactivator
with PDZ-binding motif (TAZ) can regulate cell proliferation, migration, differentiation, and …
with PDZ-binding motif (TAZ) can regulate cell proliferation, migration, differentiation, and …
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Zyxin is a member of the focal adhesion complex and plays a critical role in actin filament
polymerization and cell motility. Several recent studies showed that Zyxin is a positive …
polymerization and cell motility. Several recent studies showed that Zyxin is a positive …
Regulation of TAZ in cancer
X Zhou, QY Lei - Protein & cell, 2016 - academic.oup.com
TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW
domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway …
domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway …
Ajuba phosphorylation by CDK1 promotes cell proliferation and tumorigenesis
Recent studies identified the adaptor protein Ajuba as a positive regulator of Yes-associated
protein (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats1/2) core …
protein (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats1/2) core …
Cellular feedback dynamics and multilevel regulation driven by the hippo pathway
J Park, CG Hansen - Biochemical Society Transactions, 2021 - portlandpress.com
The Hippo pathway is a dynamic cellular signalling nexus that regulates differentiation and
controls cell proliferation and death. If the Hippo pathway is not precisely regulated, the …
controls cell proliferation and death. If the Hippo pathway is not precisely regulated, the …