Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

[HTML][HTML] The role of vaccines in combatting antimicrobial resistance

F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Alternatives to antibiotics—a pipeline portfolio review

L Czaplewski, R Bax, M Clokie, M Dawson… - The Lancet infectious …, 2016 - thelancet.com
Antibiotics have saved countless lives and enabled the development of modern medicine
over the past 70 years. However, it is clear that the success of antibiotics might only have …

Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli

MRA Karam, M Habibi, S Bouzari - Molecular immunology, 2019 - Elsevier
Urinary tract infections (UTIs) are recognized as one of the most common infectious
diseases in the world that can be divided to different types. Uropathogenic Escherichia coli …

Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus

JS McLellan, M Chen, MG Joyce, M Sastry… - science, 2013 - science.org
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5
years of age. We sought to engineer a viral antigen that provides greater protection than …

Pathogenicity Factors of Genomic Islands in Intestinal and Extraintestinal Escherichia coli

M Desvaux, G Dalmasso, R Beyrouthy… - Frontiers in …, 2020 - frontiersin.org
Escherichia coli is a versatile bacterial species that includes both harmless commensal
strains and pathogenic strains found in the gastrointestinal tract in humans and warm …

Escherichia coli in Europe: An Overview

N Allocati, M Masulli, MF Alexeyev, C Di Ilio - International journal of …, 2013 - mdpi.com
Escherichia coli remains one of the most frequent causes of several common bacterial
infections in humans and animals. E. coli is the prominent cause of enteritis, urinary tract …

E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity

A Leimbach, J Hacker, U Dobrindt - Between pathogenicity and …, 2013 - Springer
Escherichia coli is a paradigm for a versatile bacterial species which comprises harmless
commensal as well as different pathogenic variants with the ability to either cause intestinal …

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

BF Haynes, G Kelsoe, SC Harrison, TB Kepler - Nature biotechnology, 2012 - nature.com
Failure of immunization with the HIV-1 envelope to induce broadly neutralizing antibodies
against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine …

Escherichia coli from animal reservoirs as a potential source of human extraintestinal pathogenic E. coli

L Bélanger, A Garenaux, J Harel… - FEMS Immunology & …, 2011 - academic.oup.com
Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) are an important cause of
urinary tract infections, neonatal meningitis and septicaemia in humans. Animals are …