Causes and consequences of snake venom variation

NR Casewell, TNW Jackson, AH Laustsen… - Trends in …, 2020 - cell.com
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …

Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C **e, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

The rise and fall of an evolutionary innovation: contrasting strategies of venom evolution in ancient and young animals

K Sunagar, Y Moran - PLoS genetics, 2015 - journals.plos.org
Animal venoms are theorized to evolve under the significant influence of positive Darwinian
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …

The rise of genomics in snake venom research: recent advances and future perspectives

W Rao, K Kalogeropoulos, ME Allentoft… - …, 2022 - academic.oup.com
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications

K Sunagar, EAB Undheim, H Scheib, ECK Gren… - Journal of …, 2014 - Elsevier
Due to the extreme variation of venom, which consequently results in drastically variable
degrees of neutralization by CroFab antivenom, the management and treatment of …

Three-fingered RAVERs: rapid accumulation of variations in exposed residues of snake venom toxins

K Sunagar, TNW Jackson, EAB Undheim, SA Ali… - Toxins, 2013 - mdpi.com
Three-finger toxins (3FTx) represent one of the most abundantly secreted and potently toxic
components of colubrid (Colubridae), elapid (Elapidae) and psammophid (Psammophiinae …

Adaptive evolution of distinct prey-specific toxin genes in rear-fanged snake venom

CM Modahl, Mrinalini, S Frietze… - Proceedings of the …, 2018 - royalsocietypublishing.org
Venom proteins evolve rapidly, and as a trophic adaptation are excellent models for
predator–prey evolutionary studies. The key to a deeper understanding of venom evolution …

The deep-rooted origin of disulfide-rich spider venom toxins

NY Shaikh, K Sunagar - Elife, 2023 - elifesciences.org
Spider venoms are a complex concoction of enzymes, polyamines, inorganic salts, and
disulfide-rich peptides (DRPs). Although DRPs are widely distributed and abundant, their …

Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea …

M Jouiaei, K Sunagar… - Molecular biology …, 2015 - academic.oup.com
Despite Cnidaria (sea anemones, corals, jellyfish, and hydroids) being the oldest venomous
animal lineage, structure–function relationships, phyletic distributions, and the molecular …

[HTML][HTML] Centipede venom: recent discoveries and current state of knowledge

EAB Undheim, BG Fry, GF King - Toxins, 2015 - mdpi.com
Centipedes are among the oldest extant venomous predators on the planet. Armed with a
pair of modified, venom-bearing limbs, they are an important group of predatory arthropods …