Handbook of life course health development Neal Halfon· Christopher B. Forrest Richard M.
Lerner· Elaine M. Faustman Editors Handbook of Life Course Health Development Page 2 …

20 psychology (Lerner 2012), systems biology (Kitano 2002; Antony et al. 2012; Schadt and
Bjorkegren 2012), epigenetics (Egger et al. 2004), the developmental origins of chronic …

The generation of cellular diversity during development involves differentiating cells
transitioning between discrete cell states. In the 1940s, the developmental biologist Conrad …

INTRODUCTION A majority of imbalances in DNA methylation between homologous
chromosomes in humans are sequence-dependent; the DNA sequence differences between …

Epigenetic research involves examining the mitotically heritable processes that regulate
gene expression, independent of changes in the DNA sequence. Recent technical …

Understanding the mechanistic basis of epigenetic memory has proven to be a difficult task
due to the underlying complexity of the systems involved in its establishment and …

The origin of life must have involved an unlikely transition from chaotic chemistry to self-
reproducing supramolecular structures. Previous quantitative analyses of self-reproducing …

Cancer is a complex disease: its pathology cannot be properly understood in terms of
independent players—genes, proteins, molecular pathways, or their simple combinations …

A striking characteristic of cancer cells is their remarkable phenotypic plasticity, which is the
ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic …

A plant's genome encodes enzymes, transporters and many other proteins which constitute
metabolism. Interactions of plants with their environment shape their growth, development …