Primary liver cancer (PLC) is a heterogeneous group of disorders arising with the
background of chronic liver disease (CLD) owing to varying etiologies. PLC carries a high …

Immune regulation has an important role in cancer development, particularly in organs with
continuous exposure to environmental pathogens, such as the liver and gastrointestinal …

Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal
prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis …

Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver
tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options …

Breast cancer (BC) occurrence and development tremendously affect female health.
Currently breast cancer targeted drugs are still scarce. Natural products have become the …

Objective Cytotoxic agents are the cornerstone of treatment for patients with advanced
intrahepatic cholangiocarcinoma (iCCA), despite heterogeneous benefit. We hypothesised …

Background & Aims Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy,
the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse …

Cholangiocarcinoma (CCA) encompasses a heterogeneous collection of malignancies for
which diagnostic biomarkers are lacking and population screening is infeasible because of …

As a multi-substrate transmembrane protease, γ-secretase exists widely in various cells. It
controls multiple important cellular activities through substrate cleavage. γ-secretase …

Background & Aims Late diagnosis is a critical factor undermining clinical management of
patients with biliary tract cancer (BTC). While biliary tumours display extensive inter-patient …