Deep learning in proteomics

B Wen, WF Zeng, Y Liao, Z Shi, SR Savage… - …, 2020 - Wiley Online Library
Proteomics, the study of all the proteins in biological systems, is becoming a data‐rich
science. Protein sequences and structures are comprehensively catalogued in online …

QSRR: quantitative structure-(chromatographic) retention relationships

R Kaliszan - Chemical reviews, 2007 - ACS Publications
At the current state of development of chemistry, it appears easier to synthesize a compound
with a definite chemical structure than with a certain required property. Usually, reaction …

In silico spectral libraries by deep learning facilitate data-independent acquisition proteomics

Y Yang, X Liu, C Shen, Y Lin, P Yang, L Qiao - Nature communications, 2020 - nature.com
Data-independent acquisition (DIA) is an emerging technology for quantitative proteomic
analysis of large cohorts of samples. However, sample-specific spectral libraries built by …

Using i RT, a normalized retention time for more targeted measurement of peptides

C Escher, L Reiter, B MacLean, R Ossola… - …, 2012 - Wiley Online Library
Multiple reaction monitoring (MRM) has recently become the method of choice for targeted
quantitative measurement of proteins using mass spectrometry. The method, however, is …

Toward an integrated machine learning model of a proteomics experiment

BA Neely, V Dorfer, L Martens, I Bludau… - Journal of proteome …, 2023 - ACS Publications
In recent years machine learning has made extensive progress in modeling many aspects of
mass spectrometry data. We brought together proteomics data generators, repository …

Proteomics by FTICR mass spectrometry: top down and bottom up

B Bogdanov, RD Smith - Mass spectrometry reviews, 2005 - Wiley Online Library
This review provides a broad overview of recent Fourier transform ion cyclotron resonance
(FTICR) applications and technological developments relevant to the field of proteomics …

Cancer neoantigen prioritization through sensitive and reliable proteogenomics analysis

B Wen, K Li, Y Zhang, B Zhang - Nature communications, 2020 - nature.com
Genomics-based neoantigen discovery can be enhanced by proteomic evidence, but there
remains a lack of consensus on the performance of different quality control methods for …

Deep learning neural network tools for proteomics

JG Meyer - Cell Reports Methods, 2021 - cell.com
Mass-spectrometry-based proteomics enables quantitative analysis of thousands of human
proteins. However, experimental and computational challenges restrict progress in the field …

Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry

T Liu, WJ Qian, MA Gritsenko, DG Camp… - Journal of proteome …, 2005 - ACS Publications
The enormous complexity, wide dynamic range of relative protein abundances of interest
(over 10 orders of magnitude), and tremendous heterogeneity (due to post-translational …

The need for guidelines in publication of peptide and protein identification data: Working Group on Publication Guidelines for Peptide and Protein Identification Data

S Carr, R Aebersold, M Baldwin, AL Burlingame… - Molecular & Cellular …, 2004 - ASBMB
Over the past few years, the number and size of proteomic datasets composed of mass
spectrometry-derived protein identifications reported in the literature have grown …