As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

The hair follicle is not only a critical penetration route in percutaneous absorption but also
has been recognized to be a target for hair follicle-associated disorders, such as …

The skin serves as the interface between the human body and the environment and interacts
with the microbial community. The skin microbiota consists of microorganisms, such as …

Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with
various clinical presentations and combinations of symptoms. The pathophysiology of AD is …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

Hair follicle (HF) homeostasis is regulated by various signaling pathways. Disruption of such
homeostasis leads to HF disorders, such as alopecia, pigment loss, and hair aging, which is …

Alopecia areata (AA) is an autoimmune disease caused by T cell-mediated destruction of
the hair follicle (HF). Therefore, approaches that effectively disrupt pathogenic T cell …

Recent advances in our understanding of microbiome composition at sites of inflammatory
dysbiosis have triggered a substantial interest in a variety of historically understudied …

Lymphocyte decline, particularly the depletion of NK cells, is a prominent feature of
immunosuppression following severe tissue injury, heightening the susceptibility of severe …

Early life is a dynamic period for skin microbial colonization and immune development. We
postulate that microbial exposures in this period durably alter the skin immune trajectory and …