The open field is a very popular animal model of anxiety-like behavior. An overview of the
literature on the action elicited by effective or putative anxiolytics in animal subjected to this …

In anxiety research, the search for models with sufficient clinical predictive validity to support
the translation of animal studies on anxiolytic drugs to clinical research is often challenging …

Spiranthera odoratissima A. St. Hil.(manacá) is used in folk medicine to treat renal and
hepatic diseases, stomachache, headaches and rheumatism. A central nervous system …

Hippocampal processing is strongly implicated in both spatial cognition and anxiety and is
temporally organized by the theta rhythm. However, there has been little attempt to …

In our previous studies using an elevated plus-maze test in mice, taurine was shown to
present an anxiolytic-like effect after single and repeated administration [Chen SW, Kong …

Anxiolytic-like effects of dietary flavonoids are relatively well known. Ellagic acid is a
naturally occurring flavonoid compound which is abundant in many plants and fruits. The …

The gut microbiota produces metabolites that enrich the host metabolome and play a part in
host physiology, including brain functions. Yet the biological mediators of this gut-brain …

Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein …

The identification of anxious symptoms is crucial to diagnose anxiety disorders, as well as to
monitor their treatment in clinical practice and research. The aim of this review is to discuss …

Serotonergic systems in the dorsal raphe nucleus are thought to play an important role in the
regulation of anxiety states. To investigate responses of neurons in the dorsal raphe nucleus …