B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct
stages. During early embryonic development, pHSCs migrate into the fetal liver, where they …

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of
ordered gene rearrangements which must be successfully performed if the cell is to survive …

Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …

Abstracts Early B cell lymphopoiesis depends on E2A, Ebf1, Pax5 and Ikaros family
members. In the present study, we used acute protein degradation in mice to identify direct …

We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase),
which is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1 …

B cell development is a highly regulated process whereby functional peripheral subsets are
produced from hematopoietic stem cells, in the fetal liver before birth and in the bone …

Gene targeting experiments have demonstrated that the expression of immunoglobulin
heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell …

All cells continually survey their environment and make decisions based on cues
encountered. This requires specific receptors that detect such cues, then transduce signals …

The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been
conserved seemingly since the emergence of jawed vertebrates, more than 450 million …

bcl-x is a member of the bcl-2 gene family, which may regulate programmed cell death. Mice
were generated that lacked Bcl-x. The Bcl-x-deficient mice died around embryonic day 13 …