Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

Toll-like receptor stimulation in cancer: a pro-and anti-tumor double-edged sword

M Dajon, K Iribarren, I Cremer - Immunobiology, 2017 - Elsevier
Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various
pathogen-and damage-associated molecular pattern molecules playing an important role in …

[HTML][HTML] Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization

Y Liu, Q Zhou, F Ye, C Yang, H Jiang - Neoplasia, 2023 - Elsevier
We have previously demonstrated abnormal gut microbial composition in castration-
resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut …

Exploiting poly (I: C) to induce cancer cell apoptosis

F Bianchi, S Pretto, E Tagliabue, A Balsari… - Cancer biology & …, 2017 - Taylor & Francis
ABSTRACT TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune
cells where it senses pathogen-associated molecular patterns and initiates innate immune …

Targeting toll-like receptors for cancer therapy

MJ Braunstein, J Kucharczyk, S Adams - Targeted oncology, 2018 - Springer
The immune system encompasses a broad array of defense mechanisms against foreign
threats, including invading pathogens and transformed neoplastic cells. Toll-like receptors …

Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases

MC Patra, M Shah, S Choi - Seminars in cancer biology, 2020 - Elsevier
Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to
recognize pathogenic components or cellular debris and activate the immune system …

Transfected poly (I: C) activates different dsRNA receptors, leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells

S Palchetti, D Starace, P De Cesaris, A Filippini… - Journal of Biological …, 2015 - jbc.org
Despite the effectiveness of surgery or radiation therapy for the treatment of early-stage
prostate cancer (PCa), there is currently no effective strategy for late-stage disease. New …

[HTML][HTML] Toll-like receptor 3 in solid cancer and therapy resistance

XM Muresan, J Bouchal, Z Culig, K Souček - Cancers, 2020 - mdpi.com
Simple Summary Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been
extensively studied for the antiviral function and, therefore, its role in the innate and adaptive …

Roles of toll-like receptor 3 in human tumors

X Zheng, S Li, H Yang - Frontiers in immunology, 2021 - frontiersin.org
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important
group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded …

The role of apoptotic genes and protein-protein interactions in triple-negative breast cancer

GM Adinew, S Messeha, E Taka… - Cancer Genomics & …, 2023 - cgp.iiarjournals.org
Abstract Background/Aim: Compared to other breast cancer types, triple-negative breast
cancer (TNBC) has historically had few treatment alternatives. Therefore, exploring and …