This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Abstract See Nieuwhof and Helmich (doi: 10.1093/brain/awx267) for a scientific commentary
on this article. Parkinson's disease is a neurodegenerative disorder characterized by …

Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …

Parkinson's disease (PD) and atypical Parkinsonian syndromes are progressive
heterogeneous neurodegenerative diseases that share clinical characteristic of …

Functional neuroimaging techniques provide important insight into the pathophysiology of
neurodegenerative disorders such as Parkinson's disease (PD) in-vivo. Recently, resting …

The spreading hypothesis of neurodegeneration assumes an expansion of neural
pathologies along existing neural pathways. Multimodal neuroimaging studies have …

Advances in molecular and structural and functional neuroimaging are rapidly expanding
the complexity of neurobiological understanding of Parkinson's disease (PD). This review …

In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion
MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular …

Parkinson disease (PD) is a chronic and progressive movement disorder classically
characterized by slowed voluntary movements, resting tremor, muscle rigidity, and impaired …