16p11. 2 copy number variations and neurodevelopmental disorders

B Rein, Z Yan - Trends in neurosciences, 2020 - cell.com
Copy number variations (CNVs) of the human 16p11. 2 genetic locus are associated with a
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …

A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms

Y Liu, P Ouyang, Y Zheng, L Mi, J Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

J Bryois, D Calini, W Macnair, L Foo, E Urich… - Nature …, 2022 - nature.com
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky… - Elife, 2021 - elifesciences.org
The study of naturalistic social behavior requires quantification of animals' interactions. This
is generally done through manual annotation—a highly time-consuming and tedious …

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Alteration of gut microbiota: new strategy for treating autism spectrum disorder

J Liu, Z Gao, C Liu, T Liu, J Gao, Y Cai… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is defined as a complex heterogeneous disorder and
characterized by stereotyped behavior and deficits in communication and social interactions …

Microglial Tmem59 deficiency impairs phagocytosis of synapse and leads to autism-like behaviors in mice

J Meng, L Han, N Zheng, T Wang, H Xu… - Journal of …, 2022 - Soc Neuroscience
Synaptic abnormality is an important pathologic feature of autism spectrum disorders (ASDs)
and responsible for various behavioral defects in these neurodevelopmental disorders …

Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice

H Weng, L Deng, T Wang, H Xu, J Wu, Q Zhou… - Nature …, 2024 - nature.com
Climate and environmental changes threaten human mental health, but the impacts of
specific environmental conditions on neuropsychiatric disorders remain largely unclear …

Sexually dimorphic dopaminergic circuits determine sex preference

A Wei, A Zhao, C Zheng, N Dong, X Cheng, X Duan… - Science, 2025 - science.org
Sociosexual preference is critical for reproduction and survival. However, neural
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …

Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …