16p11. 2 copy number variations and neurodevelopmental disorders
Copy number variations (CNVs) of the human 16p11. 2 genetic locus are associated with a
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …
range of neurodevelopmental disorders, including autism spectrum disorder, intellectual …
A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms
Y Liu, P Ouyang, Y Zheng, L Mi, J Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …
variants contribute to gene expression, have been performed in heterogeneous brain …
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice
The study of naturalistic social behavior requires quantification of animals' interactions. This
is generally done through manual annotation—a highly time-consuming and tedious …
is generally done through manual annotation—a highly time-consuming and tedious …
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …
Alteration of gut microbiota: new strategy for treating autism spectrum disorder
J Liu, Z Gao, C Liu, T Liu, J Gao, Y Cai… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is defined as a complex heterogeneous disorder and
characterized by stereotyped behavior and deficits in communication and social interactions …
characterized by stereotyped behavior and deficits in communication and social interactions …
Microglial Tmem59 deficiency impairs phagocytosis of synapse and leads to autism-like behaviors in mice
J Meng, L Han, N Zheng, T Wang, H Xu… - Journal of …, 2022 - Soc Neuroscience
Synaptic abnormality is an important pathologic feature of autism spectrum disorders (ASDs)
and responsible for various behavioral defects in these neurodevelopmental disorders …
and responsible for various behavioral defects in these neurodevelopmental disorders …
Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice
Climate and environmental changes threaten human mental health, but the impacts of
specific environmental conditions on neuropsychiatric disorders remain largely unclear …
specific environmental conditions on neuropsychiatric disorders remain largely unclear …
Sexually dimorphic dopaminergic circuits determine sex preference
A Wei, A Zhao, C Zheng, N Dong, X Cheng, X Duan… - Science, 2025 - science.org
Sociosexual preference is critical for reproduction and survival. However, neural
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …
mechanisms encoding social decisions on sex preference remain unclear. In this study, we …
Dissecting the relationship between neuropsychiatric and neurodegenerative disorders
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …
common causes of death in elderly people, which includes progressive neuronal cell death …