Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

During the development of peripheral nerves, neural crest cells generate myelinating and
non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of …

In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse
conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

The signals that determine whether axons are ensheathed or myelinated by Schwann cells
have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

Oligodendrocytes and Schwann cells are highly specialized glial cells that wrap axons with
a multilayered myelin membrane for rapid impulse conduction. Investigators have recently …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …