Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Electrochemical biosensors for whole blood analysis: recent progress, challenges, and future perspectives

S Li, H Zhang, M Zhu, Z Kuang, X Li, F Xu… - Chemical …, 2023 - ACS Publications
Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas

A Zernecke, H Winkels, C Cochain… - Circulation …, 2020 - Am Heart Assoc
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Cytokine storm and sepsis disease pathogenesis

BG Chousterman, FK Swirski, GF Weber - Seminars in immunopathology, 2017 - Springer
Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Advances in the understanding and treatment of sepsis-induced immunosuppression

F Venet, G Monneret - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

Current gaps in sepsis immunology: new opportunities for translational research

I Rubio, MF Osuchowski, M Shankar-Hari… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation

M Dougan, G Dranoff, SK Dougan - Immunity, 2019 - cell.com
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory
responses that promote the rapid clearance of pathogens but also contribute to pathology in …