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Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
Y Wei, L Chang, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
[HTML][HTML] The chronic mild stress (CMS) model of depression: History, evaluation and usage
P Willner - Neurobiology of stress, 2017 - Elsevier
Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …
schizophrenia, affect a significant percentage of the world population. These disorders are …
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
BACKGROUND: Despite widely reported clinical and preclinical studies of rapid
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists …
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists …
Neuroinflammation and comorbidity of pain and depression
Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …
physical illness. Here, we critically examine the possibility that inflammation is the common …
The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
FX Vollenweider, M Kometer - Nature Reviews Neuroscience, 2010 - nature.com
After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent
advances in our understanding of the neurobiology of psychedelics, such as lysergic acid …
advances in our understanding of the neurobiology of psychedelics, such as lysergic acid …
Inflammation, stress and depression: an exploration of ketamine's therapeutic profile
JN Johnston, MS Greenwald, ID Henter, C Kraus… - Drug discovery today, 2023 - Elsevier
Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
Neurobiology of chronic mild stress: parallels to major depression
MN Hill, KGC Hellemans, P Verma, BB Gorzalka… - Neuroscience & …, 2012 - Elsevier
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …
animal model of depression more than 20 years ago. The foundation of this model was that …
Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes, and future challenges in improving translation
J Deslauriers, M Toth, A Der-Avakian, VB Risbrough - Biological psychiatry, 2018 - Elsevier
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …
required active collaboration between clinical and preclinical scientists. Modeling PTSD is …