Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Abstract Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe
acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry …

Inherited retinal diseases, which include retinitis pigmentosa, are a family of genetic
disorders characterized by gradual rod-cone degeneration and vision loss, without effective …

Site-Specific release of active molecules with antimicrobial activity spurred the interest in the
development of innovative polymeric nanocarriers. In the preparation of polymeric devices …

Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural
compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive …

Ca V 1.2 channels play a fundamental role in the regulation of vascular smooth muscle tone.
The aim of the present study was to synthesize morin derivatives bearing the nitrophenyl …

Chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived
actinomycete, Streptomyces griseorubens, resulted in the discovery of five new labdane …

We describe an in silico-guided rational drug design and the synthesis of the suggested
ligands, aimed at improving the TRPV1-ligand binding properties and the potency of N-(4 …

The transient receptor potential vanilloid 1 ion channel (TRPV1) is a ligand-gated
nonselective calcium-permeant cation channel involved in the detection of a wide variety of …

The sea covers more than 70% of Earth's surface and contains more than 300,000
organisms with huge biodiversity. These organisms represent an enormous tank of …