Comparative analysis of primate genomes within a phylogenetic context is essential for
understanding the evolution of human genetic architecture and primate diversity. We present …

In cis-regulatory elements, enhancers and promoters with complex molecular interactions
are used to coordinate gene transcription through physical proximity and chemical …

Although the continual expansion of the brain during primate evolution accounts for our
enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored …

Little is known about the role of non-coding regions in the etiology of autism spectrum
disorder (ASD). We examined three classes of non-coding regions: human accelerated …

Uniquely human physical traits, such as an expanded cerebral cortex and changes in limb
morphology that allow us to use tools and walk upright, are in part due to human-specific …

Transcriptional enhancers orchestrate cell type-and time point-specific gene expression
programs. Genetic variation within enhancer sequences is an important contributor to …

Nonhuman primates provide unique evolutionary and comparative insight into the human
phenotype. Genome assemblies are now available for nearly half of the species in the …

Humans have an extraordinary ability to create evolutionarily novel knowledge, such as
writing systems and mathematics. This accumulated knowledge over several millennia …

Primates are highly successful mammals with significant morphological, behavioral, and
physiological diversity. Studying the genomes of non-human primates, as the closest relative …

Although previous studies have identified human-specific accelerated regions as playing a
key role in the recent evolution of the human brain, the characteristics and cellular functions …