Highlights•Dementia involves the chronic and progressive deterioration of cognitive
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …

Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly
for intracellular protein-protein interactions too large for inhibition by small molecules, and …

Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for
which no cure is available. Inhibition or modulation of abnormal protein self-assembly …

Amyloid-β (Aβ) is a major pathological mediator of both familial and sporadic Alzheimer's
disease (AD). In the brains of AD patients, progressive accumulation of Aβ oligomers and …

Molecular tweezers represent the first class of artificial receptor molecules that have made
the way from a supramolecular host to a drug candidate with promising results in animal …

Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate
in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that …

Aggregation of α-synuclein (α-syn) is implicated as being causative in the pathogenesis of
Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. Despite …

Global epidemic studies have suggested that coffee consumption is reversely correlated
with the incidence of type 2 diabetes mellitus (T2DM), a metabolic disease. The misfolding of …

Many compounds have been tested as inhibitors or modulators of amyloid β-protein (Aβ)
assembly in hope that they would lead to effective, disease-modifying therapy for …

A combination of hydrophobic and electrostatic interactions is important in initiating the
aberrant self-assembly process that leads to formation of toxic oligomers and aggregates by …