The orbitofrontal cortex: reward, emotion and depression
The orbitofrontal cortex in primates including humans is the key brain area in emotion, and
in the representation of reward value and in non-reward, that is not obtaining an expected …
in the representation of reward value and in non-reward, that is not obtaining an expected …
The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
Background Psychological treatments occupy an important place in evidence-based mental
health treatments. Now is an exciting time to fuel treatment research: a pressing demand for …
health treatments. Now is an exciting time to fuel treatment research: a pressing demand for …
Reinforcement learning in patients with mood and anxiety disorders vs control individuals: A systematic review and meta-analysis
Importance Computational psychiatry studies have investigated how reinforcement learning
may be different in individuals with mood and anxiety disorders compared with control …
may be different in individuals with mood and anxiety disorders compared with control …
Direct and indirect pathways of basal ganglia: a critical reappraisal
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
VTA GABA neurons at the interface of stress and reward
C Bouarab, B Thompson, AM Polter - Frontiers in neural circuits, 2019 - frontiersin.org
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
The orbitofrontal cortex and emotion in health and disease, including depression
ET Rolls - Neuropsychologia, 2019 - Elsevier
The orbitofrontal cortex represents the reward or affective value of primary reinforcers
including taste, touch, texture, and face expression. It learns to associate other stimuli with …
including taste, touch, texture, and face expression. It learns to associate other stimuli with …
Reinforcement learning disruptions in individuals with depression and sensitivity to symptom change following cognitive behavioral therapy
VM Brown, L Zhu, A Solway, JM Wang… - JAMA …, 2021 - jamanetwork.com
Importance Major depressive disorder is prevalent and impairing. Parsing
neurocomputational substrates of reinforcement learning in individuals with depression may …
neurocomputational substrates of reinforcement learning in individuals with depression may …
Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of
depression is reported, with 421 patients with major depressive disorder and 488 control …
depression is reported, with 421 patients with major depressive disorder and 488 control …
Cognitive mechanisms of treatment in depression
Cognitive abnormalities are a core feature of depression, and biases toward negatively
toned emotional information are common, but are they a cause or a consequence of …
toned emotional information are common, but are they a cause or a consequence of …
Advances in the computational understanding of mental illness
Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …
computational neuroscience and machine learning into improved outcomes for patients …