Molecular mechanisms linking oxidative stress and diabetes mellitus
Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …
Molecular mechanisms of ROS production and oxidative stress in diabetes
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …
Metabolic signaling in fuel-induced insulin secretion
The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …
according to the needs of the organism. Altered insulin secretion is linked to various …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction
It is now accepted that nutrient abundance in the blood, especially glucose, leads to the
generation of reactive oxygen species (ROS), ultimately leading to increased oxidative …
generation of reactive oxygen species (ROS), ultimately leading to increased oxidative …
Oxidative stress and beta-cell dysfunction
G Drews, P Krippeit-Drews, M Düfer - Pflügers Archiv-European Journal of …, 2010 - Springer
Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …
Role of reactive oxygen species in glucose metabolism disorder in diabetic pancreatic β-cells
E Mukai, S Fujimoto, N Inagaki - Biomolecules, 2022 - mdpi.com
The dysfunction of pancreatic β-cells plays a central role in the onset and progression of
type 2 diabetes mellitus (T2DM). Insulin secretory defects in β-cells are characterized by a …
type 2 diabetes mellitus (T2DM). Insulin secretory defects in β-cells are characterized by a …
Type 2 diabetes and Alzheimer's disease: the emerging role of cellular lipotoxicity
Type 2 diabetes (T2D) and Alzheimer's diseases (AD) represent major health issues that
have reached alarming levels in the last decades. Although growing evidence demonstrates …
have reached alarming levels in the last decades. Although growing evidence demonstrates …